Ontology highlight
ABSTRACT:
SUBMITTER: Engreitz JM
PROVIDER: S-EPMC4177037 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Engreitz Jesse M JM Sirokman Klara K McDonel Patrick P Shishkin Alexander A AA Surka Christine C Russell Pamela P Grossman Sharon R SR Chow Amy Y AY Guttman Mitchell M Lander Eric S ES
Cell 20140901 1
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify these contacts, we developed a method based on RNA antisense purification to systematically map RNA-RNA interactions (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the spliceosome, and Malat1, a large ncRNA that localizes to nuclear speckles. U1 and Malat1 interact with nascent transcripts through disti ...[more]