Ontology highlight
ABSTRACT:
SUBMITTER: Kikuchi K
PROVIDER: S-EPMC4177545 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kikuchi Ken K Taniguchi Eri E Chen Hung-I Harry HH Svalina Matthew N MN Abraham Jinu J Huang Elaine T ET Nishijo Koichi K Davis Sean S Louden Christopher C Zarzabal Lee Ann LA Recht Olivia O Bajwa Ayeza A Berlow Noah N Suelves Mònica M Perkins Sherrie L SL Meltzer Paul S PS Mansoor Atiya A Michalek Joel E JE Chen Yidong Y Rubin Brian P BP Keller Charles C
Skeletal muscle 20131125 1
<h4>Background</h4>Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a.<h4>Methods</h4>We investigated the complementary role of Rb1 loss in aRMS tumor initiation and progression using conditional mouse models.<h4>Results</h4>Rb1 loss was not a necessary and sufficient mutational event for rhabdomyosarcomagenesis, nor a strong cooperative initiating mutation. Instead, Rb1 loss was a modifier of progression ...[more]