Clinical development of phosphatidylinositol 3-kinase inhibitors for non-Hodgkin lymphoma.
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ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC4177547 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Clinical development of phosphatidylinositol 3-kinase inhibitors for non-Hodgkin lymphoma.
Fang Xiaosheng X Zhou Xiangxiang X Wang Xin X
Biomarker research 20131115 1
Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is extensively explored in cancers. It functions as an important regulator of cell growth, survival and metabolism. Activation of this pathway also predicts poor prognosis in numerous human malignancies. Drugs targeting this signaling pathway have been developed and have shown preliminary clinical activity. Accumulating evidence has highlighted the important role of PI3K in non-Hodgkin lymphoma (NHL), ...[more]
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