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Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals.


ABSTRACT: The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, México and Perú). These individuals were also characterized for a range of physical appearance traits and for self-perception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry.

SUBMITTER: Ruiz-Linares A 

PROVIDER: S-EPMC4177621 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals.

Ruiz-Linares Andrés A   Adhikari Kaustubh K   Acuña-Alonzo Victor V   Quinto-Sanchez Mirsha M   Jaramillo Claudia C   Arias William W   Fuentes Macarena M   Pizarro María M   Everardo Paola P   de Avila Francisco F   Gómez-Valdés Jorge J   León-Mimila Paola P   Hunemeier Tábita T   Ramallo Virginia V   Silva de Cerqueira Caio C CC   Burley Mari-Wyn MW   Konca Esra E   de Oliveira Marcelo Zagonel MZ   Veronez Mauricio Roberto MR   Rubio-Codina Marta M   Attanasio Orazio O   Gibbon Sahra S   Ray Nicolas N   Gallo Carla C   Poletti Giovanni G   Rosique Javier J   Schuler-Faccini Lavinia L   Salzano Francisco M FM   Bortolini Maria-Cátira MC   Canizales-Quinteros Samuel S   Rothhammer Francisco F   Bedoya Gabriel G   Balding David D   Gonzalez-José Rolando R  

PLoS genetics 20140925 9


The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, México and Perú). These individuals were also characterized for a range of physical appearance traits and for self-perception of a  ...[more]

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