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Image-based left ventricular shape analysis for sudden cardiac death risk stratification.

ABSTRACT: Low left ventricular ejection fraction (LVEF), the main criterion used in the current clinical practice to stratify sudden cardiac death (SCD) risk, has low sensitivity and specificity.To uncover indices of left ventricular (LV) shape that differ between patients with a high risk of SCD and those with a low risk.By using clinical cardiac magnetic resonance imaging and computational anatomy tools, a novel computational framework to compare 3-dimensional LV endocardial surface curvedness, wall thickness, and relative wall thickness between patient groups was implemented. The framework was applied to cardiac magnetic resonance data of 61 patients with ischemic cardiomyopathy who were selected for prophylactic implantable cardioverter-defibrillator treatment on the basis of reduced LVEF. The patients were classified by outcome: group 0 had no events; group 1, arrhythmic events; and group 2, heart failure events. Segmental differences in LV shape were assessed.Global LV volumes and mass were similar among groups. Compared with patients with no events, patients in groups 1 and 2 had lower mean shape metrics in all coronary artery regions, with statistical significance in 9 comparisons, reflecting wall thinning and stretching/flattening.In patients with ischemic cardiomyopathy and low LVEF, there exist quantifiable differences in 3-dimensional endocardial surface curvedness, LV wall thickness, and LV relative wall thickness between those with no clinical events and those with arrhythmic or heart failure outcomes, reflecting adverse LV remodeling. This retrospective study is a proof of concept to demonstrate that regional LV remodeling indices have the potential to improve the personalized risk assessment for SCD.

SUBMITTER: Vadakkumpadan F

PROVIDER: S-EPMC4177952 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Image-based left ventricular shape analysis for sudden cardiac death risk stratification.

Vadakkumpadan Fijoy F Trayanova Natalia N Wu Katherine C KC

Heart rhythm 20140520 10

<h4>Background</h4>Low left ventricular ejection fraction (LVEF), the main criterion used in the current clinical practice to stratify sudden cardiac death (SCD) risk, has low sensitivity and specificity.<h4>Objective</h4>To uncover indices of left ventricular (LV) shape that differ between patients with a high risk of SCD and those with a low risk.<h4>Methods</h4>By using clinical cardiac magnetic resonance imaging and computational anatomy tools, a novel computational framework to compare 3-di ...[more]

PMID: 24854217

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Project description:BackgroundMaximal left ventricular wall thickness (MLVWT) is a risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). In adults, the severity of left ventricular hypertrophy has a nonlinear relationship with SCD, but it is not known whether the same complex relationship is seen in childhood. The aim of this study was to describe the relationship between left ventricular hypertrophy and SCD risk in a large international pediatric HCM cohort.MethodsThe study cohort comprised 1075 children (mean age, 10.2 years [±4.4]) diagnosed with HCM (1-16 years) from the International Paediatric Hypertrophic Cardiomyopathy Consortium. Anonymized, noninvasive clinical data were collected from baseline evaluation and follow-up, and 5-year estimated SCD risk was calculated (HCM Risk-Kids).ResultsMLVWT Z score was <10 in 598 (58.1%), ≥10 to <20 in 334 (31.1%), and ≥20 in 143 (13.3%). Higher MLVWT Z scores were associated with heart failure symptoms, unexplained syncope, left ventricular outflow tract obstruction, left atrial dilatation, and nonsustained ventricular tachycardia. One hundred twenty-two patients (71.3%) with MLVWT Z score ≥20 had coexisting risk factors for SCD. Over a median follow-up of 4.9 years (interquartile range, 2.3-9.3), 115 (10.7%) had an SCD event. Freedom from SCD event at 5 years for those with MLVWT Z scores <10, ≥10 to <20, and ≥20 was 95.6%, 87.4%, and 86.0, respectively. The estimated SCD risk at 5 years had a nonlinear, inverted U-shaped relationship with MLVWT Z score, peaking at Z score +23. The presence of coexisting risk factors had a summative effect on risk.ConclusionsIn children with HCM, an inverted U-shaped relationship exists between left ventricular hypertrophy and estimated SCD risk. The presence of additional risk factors has a summative effect on risk. While MLVWT is important for risk stratification, it should not be used either as a binary variable or in isolation to guide implantable cardioverter defibrillator implantation decisions in children with HCM.

Dataset Information

Image-based left ventricular shape analysis for sudden cardiac death risk stratification.

Publications

Image-based left ventricular shape analysis for sudden cardiac death risk stratification.

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