Ontology highlight
ABSTRACT:
SUBMITTER: Mahe F
PROVIDER: S-EPMC4178461 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mahé Frédéric F Rognes Torbjørn T Quince Christopher C de Vargas Colomban C Dunthorn Micah M
PeerJ 20140925
Popular de novo amplicon clustering methods suffer from two fundamental flaws: arbitrary global clustering thresholds, and input-order dependency induced by centroid selection. Swarm was developed to address these issues by first clustering nearly identical amplicons iteratively using a local threshold, and then by using clusters' internal structure and amplicon abundances to refine its results. This fast, scalable, and input-order independent approach reduces the influence of clustering paramet ...[more]