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Structural insights into the human metapneumovirus glycoprotein ectodomain.

ABSTRACT: Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G) modulates innate and adaptive immune responses, leading to incomplete immunity and promoting reinfection. Using bioinformatics analyses, static light scattering, and small-angle X-ray scattering, we show that the extracellular region of G behaves as a heavily glycosylated, intrinsically disordered polymer. We discuss potential implications of these findings for the modulation of immune responses by G.

SUBMITTER: Leyrat C

PROVIDER: S-EPMC4178817 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Structural insights into the human metapneumovirus glycoprotein ectodomain.

Leyrat Cedric C Paesen Guido C GC Charleston James J Renner Max M Grimes Jonathan M JM

Journal of virology 20140716 19

Human metapneumovirus is a major cause of respiratory tract infections worldwide. Previous reports have shown that the viral attachment glycoprotein (G) modulates innate and adaptive immune responses, leading to incomplete immunity and promoting reinfection. Using bioinformatics analyses, static light scattering, and small-angle X-ray scattering, we show that the extracellular region of G behaves as a heavily glycosylated, intrinsically disordered polymer. We discuss potential implications of th ...[more]

PMID: 25031352

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Human metapneumovirus glycoprotein G inhibits innate immune responses.

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