Dataset Information

Endothelial morphometric measures to predict endothelial graft failure after penetrating keratoplasty.

ABSTRACT:

Importance

Endothelial morphometric measures have potential value in predicting graft failure after penetrating keratoplasty.

Objective

To determine whether preoperative and/or postoperative central morphometric measures (endothelial cell density [ECD], coefficient of variation [CV], and percentage of hexagonality [HEX]) and their postoperative changes are predictive of graft failure caused by endothelial decompensation after penetrating keratoplasty to treat a moderate-risk condition, principally Fuchs dystrophy or pseudophakic corneal edema.

Design

In a subset of Cornea Donor Study participants with graft failure, a central reading center determined preoperative and postoperative ECD, CV, and HEX from available central endothelial specular images.