Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283.
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ABSTRACT:
SUBMITTER: Petersen W
PROVIDER: S-EPMC4179499 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
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Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283.
Petersen William W Liu Jingbo J Yuan Liangping L Zhang Hongying H Schneiderjan Matthew M Cho Yoon-Jae YJ MacDonald Tobey J TJ
Cancer letters 20140810 1
Medulloblastoma (MB) expresses Src kinase, while aurora kinase A overexpression correlates with poor survival. We thus investigated novel combination treatment with dasatinib and AT9283, inhibitors of Src and aurora kinase, respectively, on MB growth in vitro and in vivo. Treatment with each drug significantly reduced cell viability and combined treatment markedly potentiated this response. AT9283 induced p53 expression, autophagy, and G2/M cell-cycle arrest, while combined treatment induced S p ...[more]
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