Ontology highlight
ABSTRACT:
SUBMITTER: Cassese A
PROVIDER: S-EPMC4179607 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Cassese Alberto A Guindani Michele M Vannucci Marina M
Cancer informatics 20140921 Suppl 2
We consider a Bayesian hierarchical model for the integration of gene expression levels with comparative genomic hybridization (CGH) array measurements collected on the same subjects. The approach defines a measurement error model that relates the gene expression levels to latent copy number states. In turn, the latent states are related to the observed surrogate CGH measurements via a hidden Markov model. The model further incorporates variable selection with a spatial prior based on a probit l ...[more]