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Preparation and characterization of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds.


ABSTRACT: Silver nanoparticles (AgNPs)-loaded alginate beads embedded in gelatin scaffolds were successfully prepared. The AgNPs-loaded calcium alginate beads were prepared by electrospraying method. The effect of alginate concentration and applied voltage on shape and diameter of beads was studied. The diameter of dry AgNPs-loaded calcium alignate beads at various concentrations of AgNO3 ranged between 154 and 171 ?m. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated by freeze-drying method. The water swelling and weight loss behaviors of the AgNPs-loaded alginate beads embedded in gelatin scaffolds increased with an increase in the submersion time. Moreover, the genipin-cross-linked gelatin scaffolds were proven to be nontoxic to normal human dermal fibroblasts, suggesting their potential uses as wound dressings.

SUBMITTER: Pankongadisak P 

PROVIDER: S-EPMC4179659 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Preparation and characterization of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds.

Pankongadisak Porntipa P   Ruktanonchai Uracha Rungsardthong UR   Supaphol Pitt P   Suwantong Orawan O  

AAPS PharmSciTech 20140523 5


Silver nanoparticles (AgNPs)-loaded alginate beads embedded in gelatin scaffolds were successfully prepared. The AgNPs-loaded calcium alginate beads were prepared by electrospraying method. The effect of alginate concentration and applied voltage on shape and diameter of beads was studied. The diameter of dry AgNPs-loaded calcium alignate beads at various concentrations of AgNO3 ranged between 154 and 171 μm. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated b  ...[more]

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