Ontology highlight
ABSTRACT:
SUBMITTER: Zheng C
PROVIDER: S-EPMC4180751 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Zheng Chengkun C Xu Jiali J Li Jinquan J Hu Luohong L Xia Jiandong J Fan Jingyan J Guo Weina W Chen Huanchun H Bei Weicheng W
PloS one 20140929 9
Streptococcus suis serotype 2 is an important zoonotic pathogen causing severe infections in pigs and humans. The pathogenesis of S. suis 2 infections, however, is still poorly understood. Spx proteins are a group of global regulators involved in stress tolerance and virulence. In this study, we characterized two orthologs of the Spx regulator, SpxA1 and SpxA2 in S. suis 2. Two mutant strains (ΔspxA1 and ΔspxA2) lacking the spx genes were constructed. The ΔspxA1 and ΔspxA2 mutants displayed diff ...[more]