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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

ABSTRACT: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

SUBMITTER: Wang H 

PROVIDER: S-EPMC4180879 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

Wang Hansong H   Burnett Terrilea T   Kono Suminori S   Haiman Christopher A CA   Iwasaki Motoki M   Wilkens Lynne R LR   Loo Lenora W M LW   Van Den Berg David D   Kolonel Laurence N LN   Henderson Brian E BE   Keku Temitope O TO   Sandler Robert S RS   Signorello Lisa B LB   Blot William J WJ   Newcomb Polly A PA   Pande Mala M   Amos Christopher I CI   West Dee W DW   Bézieau Stéphane S   Berndt Sonja I SI   Zanke Brent W BW   Hsu Li L   Lindor Noralane M NM   Haile Robert W RW   Hopper John L JL   Jenkins Mark A MA   Gallinger Steven S   Casey Graham G   Stenzel Stephanie L SL   Schumacher Fredrick R FR   Peters Ulrike U   Gruber Stephen B SB   Tsugane Shoichiro S   Stram Daniel O DO   Le Marchand Loïc L  

Nature communications 20140808

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This stu  ...[more]

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