Ontology highlight
ABSTRACT:
SUBMITTER: Garcia I
PROVIDER: S-EPMC4182170 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Garcia Isabella I Quast Kathleen B KB Huang Longwen L Herman Alexander M AM Selever Jennifer J Deussing Jan M JM Justice Nicholas J NJ Arenkiel Benjamin R BR
Developmental cell 20140904 6
Neural activity either enhances or impairs de novo synaptogenesis and circuit integration of neurons, but how this activity is mechanistically relayed in the adult brain is largely unknown. Neuropeptide-expressing interneurons are widespread throughout the brain and are key candidates for conveying neural activity downstream via neuromodulatory pathways that are distinct from classical neurotransmission. With the goal of identifying signaling mechanisms that underlie neuronal circuit integration ...[more]