Unknown

Dataset Information

0

Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.


ABSTRACT: Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface-engineered Au NRs with polyethylenimine are synthesized using a layer-by-layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near-infrared (NIR) light, causing heat-induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.

SUBMITTER: Shen J 

PROVIDER: S-EPMC4182177 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.

Shen Jianliang J   Kim Han-Cheon HC   Mu Chaofeng C   Gentile Emanuela E   Mai Junhua J   Wolfram Joy J   Ji Liang-nian LN   Ferrari Mauro M   Mao Zong-wan ZW   Shen Haifa H  

Advanced healthcare materials 20140401 10


Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface-engineered Au NRs with polyethylenimine are synthesized using a layer-by-layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with nea  ...[more]

Similar Datasets

| S-EPMC4097346 | biostudies-other
| S-EPMC5995181 | biostudies-literature
| S-EPMC10057058 | biostudies-literature
| S-EPMC8630206 | biostudies-literature
| S-EPMC9163824 | biostudies-literature
| S-EPMC8477545 | biostudies-literature
| S-EPMC4278682 | biostudies-literature
| S-EPMC6278843 | biostudies-other
| S-EPMC7439364 | biostudies-literature
| S-EPMC9091941 | biostudies-literature