Unknown

Dataset Information

0

Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone.


ABSTRACT: Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (GH) show substantially faster growth than wild-type (WT) fish. We fed GH-transgenic salmon either to satiation (1 year; TF) or the same smaller ration of wild-type fish (2 years; TR), resulting in groups matched for body size to WT salmon. The myotomes of TF and WT fish had the same number and size distribution of muscle fibres, indicating a twofold higher rate of fibre recruitment in the GH transgenics. Unexpectedly, calorie restriction was found to decrease the rate of fibre production in transgenics, resulting in a 20% increase in average fibre size and reduced costs of ionic homeostasis. Genes for myotube formation were downregulated in TR relative to TF and WT fish. We suggest that muscle fibre size optimisation allows the reallocation of energy from maintenance to locomotion, explaining the observation that calorie-restricted transgenics grow at the same rate as WT fish whilst exhibiting markedly higher foraging activity.

SUBMITTER: Johnston IA 

PROVIDER: S-EPMC4182283 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Muscle fibre size optimisation provides flexibility for energy budgeting in calorie-restricted coho salmon transgenic for growth hormone.

Johnston Ian A IA   de la Serrana Daniel Garcia DG   Devlin Robert H RH  

The Journal of experimental biology 20140807 Pt 19


Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (GH) show substantially faster growth than wild-type (WT) fish. We fed GH-transgenic salmon either to satiation (1 year; TF) or the same smaller ration of wild-type fish (2 years; TR), resulting in groups matched for body size to WT salmon. The myotomes of TF and WT fish had the same number and size distribution of muscle fibres, indicating a twofold higher rate of fibre recruitment in the GH transgenics. Unexpectedly, calorie rest  ...[more]

Similar Datasets

| PRJEB7712 | ENA
2005-05-01 | GSE2388 | GEO
| S-EPMC438972 | biostudies-other
| S-EPMC5222502 | biostudies-literature
| S-EPMC6935076 | biostudies-literature
2005-12-31 | GSE3477 | GEO
| S-EPMC4555853 | biostudies-literature
2021-08-16 | GSE168262 | GEO
2008-03-19 | GSE1089 | GEO
2005-01-10 | GSE1087 | GEO