Ontology highlight
ABSTRACT:
SUBMITTER: Wong D
PROVIDER: S-EPMC4182881 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wong David D Winter Oliver O Hartig Christina C Siebels Svenja S Szyska Martin M Tiburzy Benjamin B Meng Lingzhang L Kulkarni Upasana U Fähnrich Anke A Bommert Kurt K Bargou Ralf R Berek Claudia C Chu Van Trung VT Bogen Bjarne B Jundt Franziska F Manz Rudolf Armin RA
PloS one 20141001 10
Multiple myeloma is a bone marrow plasma cell tumor which is supported by the external growth factors APRIL and IL-6, among others. Recently, we identified eosinophils and megakaryocytes to be functional components of the micro-environmental niches of benign bone marrow plasma cells and to be important local sources of these cytokines. Here, we investigated whether eosinophils and megakaryocytes also support the growth of tumor plasma cells in the MOPC315.BM model for multiple myeloma. As it was ...[more]