Ontology highlight
ABSTRACT:
SUBMITTER: White S
PROVIDER: S-EPMC4182958 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
White Simone S Acierno Ron R Ruggiero Kenneth J KJ Koenen Karestan C KC Kilpatrick Dean G DG Galea Sandro S Gelernter Joel J Williamson Vernell V McMichael Omari O Vladimirov Vladimir I VI Amstadter Ananda B AB
Journal of anxiety disorders 20130827 7
Posttraumatic stress disorder (PTSD) is a moderately heritable anxiety disorder that may develop after exposure to trauma. However, only few genetic variants that relate to PTSD have been studied. This study examined the relationship between 12 single nucleotide polymorphisms (SNPs) in the corticotropin-releasing hormone receptor 1 gene (CRHR1) and post-disaster PTSD symptoms and diagnosis in adults exposed to 2004 Florida hurricanes. CRHR1 regulates the hypothalamic-pituitary-adrenal (HPA) axis ...[more]