Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesan M
PROVIDER: S-EPMC4183414 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Venkatesan Meera M Gadalla Nahla B NB Stepniewska Kasia K Dahal Prabin P Nsanzabana Christian C Moriera Clarissa C Price Ric N RN Mårtensson Andreas A Rosenthal Philip J PJ Dorsey Grant G Sutherland Colin J CJ Guérin Philippe P Davis Timothy M E TME Ménard Didier D Adam Ishag I Ademowo George G Arze Cesar C Baliraine Frederick N FN Berens-Riha Nicole N Björkman Anders A Borrmann Steffen S Checchi Francesco F Desai Meghna M Dhorda Mehul M Djimdé Abdoulaye A AA El-Sayed Badria B BB Eshetu Teferi T Eyase Frederick F Falade Catherine C Faucher Jean-François JF Fröberg Gabrielle G Grivoyannis Anastasia A Hamour Sally S Houzé Sandrine S Johnson Jacob J Kamugisha Erasmus E Kariuki Simon S Kiechel Jean-René JR Kironde Fred F Kofoed Poul-Erik PE LeBras Jacques J Malmberg Maja M Mwai Leah L Ngasala Billy B Nosten Francois F Nsobya Samuel L SL Nzila Alexis A Oguike Mary M Otienoburu Sabina Dahlström SD Ogutu Bernhards B Ouédraogo Jean-Bosco JB Piola Patrice P Rombo Lars L Schramm Birgit B Somé A Fabrice AF Thwing Julie J Ursing Johan J Wong Rina P M RPM Zeynudin Ahmed A Zongo Issaka I Plowe Christopher V CV Sibley Carol Hopkins CH Asaq Molecular Marker Study Group
The American journal of tropical medicine and hygiene 20140721 4
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly ...[more]