Ontology highlight
ABSTRACT:
SUBMITTER: Lin CY
PROVIDER: S-EPMC4183429 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Lin Chia-Yeh CY Wu Meng-Ying MY Gay Sophie S Marjavaara Lisette L Lai Mong Sing MS Hsiao Wei-Chun WC Hung Shih-Hsun SH Tseng Hsin-Yi HY Wright Duncan Edward DE Wang Chen-Yi CY Hsu Guoo-Shyng W GS Devys Didier D Chabes Andrei A Kao Cheng-Fu CF
PLoS genetics 20141002 10
The influence of mono-ubiquitylation of histone H2B (H2Bub) on transcription via nucleosome reassembly has been widely documented. Recently, it has also been shown that H2Bub promotes recovery from replication stress; however, the underling molecular mechanism remains unclear. Here, we show that H2B ubiquitylation coordinates activation of the intra-S replication checkpoint and chromatin re-assembly, in order to limit fork progression and DNA damage in the presence of replication stress. In part ...[more]