Mammary stem cells have myoepithelial cell properties.
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ABSTRACT:
SUBMITTER: Prater MD
PROVIDER: S-EPMC4183554 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Mammary stem cells have myoepithelial cell properties.
Prater Michael D MD Petit Valérie V Alasdair Russell I I Giraddi Rajshekhar R RR Shehata Mona M Menon Suraj S Schulte Reiner R Kalajzic Ivo I Rath Nicola N Olson Michael F MF Metzger Daniel D Faraldo Marisa M MM Deugnier Marie-Ange MA Glukhova Marina A MA Stingl John J
Nature cell biology 20140831 10
Contractile myoepithelial cells dominate the basal layer of the mammary epithelium and are considered to be differentiated cells. However, we observe that up to 54% of single basal cells can form colonies when seeded into adherent culture in the presence of agents that disrupt actin-myosin interactions, and on average, 65% of the single-cell-derived basal colonies can repopulate a mammary gland when transplanted in vivo. This indicates that a high proportion of basal myoepithelial cells can give ...[more]
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