Association of NCAM1 polymorphisms with autism and parental age at conception in a Chinese Han population.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4183898 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Association of NCAM1 polymorphisms with autism and parental age at conception in a Chinese Han population.
Zhang Jishui J Wang Aihua A Li Yan Y Lu Xiaoyan X Wang Fang F Fang Fang F
Genetic testing and molecular biomarkers 20140819 10
<h4>Aims</h4>The neural cell adhesion molecule (NCAM) has been reported to be involved in the development of the central nervous system and its mRNA level might decrease in the serum of autistic patients. However, there was no evidence of the association of the NCAM1 gene polymorphisms with autism. In the present study, we enrolled 237 children with autism and 451 healthy control subjects. Then, we used the direct DNA sequencing for genotyping five tag single-nucleotide polymorphisms (SNPs) in t ...[more]
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