Drug repositioning by integrating target information through a heterogeneous network model.

ABSTRACT:

Motivation

The emergence of network medicine not only offers more opportunities for better and more complete understanding of the molecular complexities of diseases, but also serves as a promising tool for identifying new drug targets and establishing new relationships among diseases that enable drug repositioning. Computational approaches for drug repositioning by integrating information from multiple sources and multiple levels have the potential to provide great insights to the complex relationships among drugs, targets, disease genes and diseases at a system level.

Results

In this article, we have proposed a computational framework based on a heterogeneous network model and applied the approach on drug repositioning by using existing omics data about diseases, drugs and

SUBMITTER: Wang W 

PROVIDER: S-EPMC4184255 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature