Ontology highlight
ABSTRACT:
SUBMITTER: Charni Chaabane S
PROVIDER: S-EPMC4184810 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Charni Chaabane Saima S Coomans de Brachène Alexandra A Essaghir Ahmed A Velghe Amélie A Lo Re Sandra S Stockis Julie J Lucas Sophie S Khachigian Levon M LM Huaux François F Demoulin Jean-Baptiste JB
PloS one 20141003 10
Transforming growth factor-β (TGFβ) is a key mediator of fibrogenesis. TGFβ is overexpressed and activated in fibrotic diseases, regulates fibroblast differentiation into myofibroblasts and induces extracellular matrix deposition. Platelet-derived growth factor (PDGF) is also a regulator of fibrogenesis. Some studies showed a link between TGFβ and PDGF in certain fibrotic diseases. TGFβ induces PDGF receptor alpha expression in scleroderma fibroblasts. PDGF-C and -D are the most recently discove ...[more]