Ontology highlight
ABSTRACT:
SUBMITTER: Baker GJ
PROVIDER: S-EPMC4184887 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Baker Gregory J GJ Chockley Peter P Yadav Viveka Nand VN Doherty Robert R Ritt Michael M Sivaramakrishnan Sivaraj S Castro Maria G MG Lowenstein Pedro R PR
Cancer research 20140718 18
Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance. However, the immune escape mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain unclear. Here we show that malignant glioma cells suppress NK immune surveillance by overexpressing the β-galactoside-binding lectin galectin-1. Conversely, galectin-1-deficient glioma cells could be eradicated by ho ...[more]