Ontology highlight
ABSTRACT:
SUBMITTER: Ortega Arroyo J
PROVIDER: S-EPMC4186656 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ortega Arroyo J J Andrecka J J Spillane K M KM Billington N N Takagi Y Y Sellers J R JR Kukura P P
Nano letters 20140321 4
Optical detection of individual proteins requires fluorescent labeling. Cavity and plasmonic methodologies enhance single molecule signatures in the absence of any labels but have struggled to demonstrate routine and quantitative single protein detection. Here, we used interferometric scattering microscopy not only to detect but also to image and nanometrically track the motion of single myosin 5a heavy meromyosin molecules without the use of labels or any nanoscopic amplification. Together with ...[more]