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Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia.

ABSTRACT: Despite vast improvements in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML) in chronic phase (CP), advanced stages of CML, accelerated phase or blast crisis, remain notoriously difficult to treat. Treatments that are highly effective against CML-CP produce disappointing results against advanced disease. Therefore, a primary goal of therapy should be to maintain patients in CP for as long as possible, by (1) striving for deep, early molecular response to treatment; (2) using tyrosine kinase inhibitors that lower risk of disease progression; and (3) more closely observing patients who demonstrate cytogenetic risk factors at diagnosis or during treatment.

SUBMITTER: Jabbour EJ

PROVIDER: S-EPMC4186697 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia.

Jabbour Elias J EJ Hughes Timothy P TP Cortés Jorge E JE Kantarjian Hagop M HM Hochhaus Andreas A

Leukemia & lymphoma 20131112 7

Despite vast improvements in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML) in chronic phase (CP), advanced stages of CML, accelerated phase or blast crisis, remain notoriously difficult to treat. Treatments that are highly effective against CML-CP produce disappointing results against advanced disease. Therefore, a primary goal of therapy should be to maintain patients in CP for as long as possible, by (1) striving for deep, early molecular response to treatmen ...[more]

PMID: 24050507

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