Ontology highlight
ABSTRACT:
SUBMITTER: Kage H
PROVIDER: S-EPMC4187039 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kage Hidenori H Flodby Per P Gao Danping D Kim Yong Ho YH Marconett Crystal N CN DeMaio Lucas L Kim Kwang-Jin KJ Crandall Edward D ED Borok Zea Z
American journal of physiology. Lung cellular and molecular physiology 20140808 7
Claudins are tight junction proteins that regulate paracellular ion permeability of epithelium and endothelium. Claudin 4 has been reported to function as a paracellular sodium barrier and is one of three major claudins expressed in lung alveolar epithelial cells (AEC). To directly assess the role of claudin 4 in regulation of alveolar epithelial barrier function and fluid homeostasis in vivo, we generated claudin 4 knockout (Cldn4 KO) mice. Unexpectedly, Cldn4 KO mice exhibited normal physiolog ...[more]