Dataset Information

Association between serum ?-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

ABSTRACT:

Objective

The purpose of this study was to determine the relationship between serum ?-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.

Design

A cross-sectional study.

Setting

A health check-up centre in Japan.

Participants

912 Japanese men and women aged 24-84?years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV.

Main outcome measures

We measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1?year after the cessation of menses.

Results

In women, log2 GGT was positively associated with baPWV (?=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log2 GGT with baPWV was not significant (?=-0.04, 95% CI -0.10 to 0.03, p=0.28) in multivariable linear regression analyses.

Conclusions

The serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.

SUBMITTER: Fukuda T

PROVIDER: S-EPMC4187458 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

Fukuda Takuya T Hamaguchi Masahide M Kojima Takao T Ohshima Yasuhiro Y Ohbora Akihiro A Kato Takahiro T Nakamura Naoto N Fukui Michiaki M

BMJ open 20141003 10

<h4>Objective</h4>The purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.<h4>Design</h4>A cross-sectional study.<h4>Setting</h4>A health check-up centre in Japan.<h4>Participants</h4>912 Japanese men and women aged 24-84 years recruited from people who received a medical health check-up programme with a stan ...[more]

PMID: 25280803

Similar Datasets

Project description:Background"Hypertriglyceridemic waist" (HTGW) phenotype, an inexpensive early screening tool for detection of individuals at risk for type 2 diabetes and cardiovascular disease was found to be associated with subclinical atherosclerosis in various patient populations such as those with diabetes mellitus, chronic kidney disease, and those infected with human immunodeficiency virus. However, less is known regarding an association between HTGW and subclinical atherosclerosis in the apparently healthy, multiethnic population. Therefore, the aim of the study was to explore the association between HTGW and sub-clinical atherosclerosis in an apparently healthy, multiethnic population; and to investigate whether the effect of HTGW on sub-clinical atherosclerosis persists over and above the traditional atherosclerosis risk factors.MethodsWe studied 809 individuals of Aboriginal, Chinese, European and South Asian origin who were assessed for indices of sub-clinical atherosclerosis (intima-media thickness (IMT), total area and presence of carotid plaques), socio-demographic and lifestyle characteristics, anthropometrics, lipids, glucose, blood pressure, and family history of cardiovascular disease.ResultsWe found that, compared to individuals without HTGW and after adjusting for age, ethnicity, smoking, and physical activity; men and women with HTGW had a significantly higher: IMT (men: B (95%CI?=?0.084 (0.037, 1.133), p?<?0.001; women: B (95%CI)?=?0.041 (0.006, 0.077), p?=?0.020); and total area (men: B (95%CI?=?0.202 (0.058, 0.366), p?=?0.005; women: B (95%CI)?=?0.115 (0.006, 0.235), p?=?0.037). The association between HTGW waist and presence of plaques was significant for men (OR (95%CI)?=?1.904 (1.040, 3.486), p?=?0.037 vs. men without HTGW), but not for women (p?=?0.284). Once analyses were adjusted for additional, traditional risk factors for atherosclerosis, the effect of HTGW on sub-clinical atherosclerosis was no longer significant.ConclusionsIn conclusion, HTGW may serve as an early marker of subclinical atherosclerosis in men and women, irrespective of ethnicity. However, once individuals are assessed for all traditional risk factors for atherosclerosis, the additional assessment for HTGW is not warranted.

Project description:ObjectiveHypertension is a major risk factor and cause of many non-communicable diseases in China. While there have been studies on various diet and lifestyle risk factors, we do not know whether sleep duration has an association to blood pressure in southwest China. This predictor is useful in low-resource rural settings. We examined the association between sleep duration and hypertension in southwest China.DesignPopulation-based cross-sectional study.SettingThis study was part of the baseline survey of a large ongoing prospective cohort study, the China Kadoorie Biobank. Participants were enrolled in 15 townships of Pengzhou city in Sichuan province during 2004-2008.Participants55 687 participants aged 30-79 years were included. Sleep duration was assessed by a self-reported questionnaire.Main outcome measuresHypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or prior physician-diagnosed hypertension in hospitals at the township (community) level or above.ResultsThe prevalence of hypertension was 25.17%. The percentages of subjects with sleep durations of <6, 6, 7, 8 and ≥9 hours were 17.20%, 16.14%, 20.04%, 31.95% and 14.67%, respectively. In multivariable-adjusted analyses, the increased ORs of having hypertension were across those who reported ≥9 hours of sleep (men: 1.16, 95% CI 1.04 to 1.30; women: 1.19, 95% CI 1.08 to 1.32; general population: 1.17, 95% CI 1.08 to 1.26). The odds of hypertension was relatively flat until around 6.81 hours of sleep duration and then started to increase rapidly afterwards in subjects and a J-shaped pattern was observed. There was a U-shaped relationship between sleep duration and hypertension in females.ConclusionLong sleep duration was significantly associated with hypertension and a J-shaped pattern was observed among rural adults in southwest China, independent of potential confounders. However, this association was not obvious between short sleep duration and hypertension.

Project description:OBJECTIVE:To investigate the association between maternal education and breast feeding in the Chinese population, with a consideration of household income and health-seeking behaviours. DESIGN:A nationally representative population-based cross-sectional study. SETTING:77 counties from 12 geographically distinct regions in China. PARTICIPANTS:10?408 mothers with children from 0 to 12 months of age, aged 15-53 years old (mean: 29.15, SD: 5.11) were classified into primary school or below group (n=781), middle school group (n=3842), high school/vocational school group (n=1990), college or above group (n=3795), according to their highest completed education. OUTCOMES:Five breastfeeding outcomes, including early initiation of breast feeding (EIB), exclusive breast feeding (EBF) under 6?months, predominant breast feeding under 6?months, current breast feeding and children ever breast fed, were calculated based on the standardised questionnaire from the WHO and Wellstart International's toolkit for monitoring and evaluating breastfeeding activities. RESULTS:The absolute risk of EIB and EBF in the lowest maternal education level was 64.85% and 26.53%, respectively, whereas the absolute risk of EIB and EBF in the highest maternal education level was 77.21% and 14.06%, respectively. A higher level of maternal education was positively associated with EIB (risk ratio (RR): 1.22; 95%?CI: 1.12 to 1.30) and was inversely associated with EBF (RR: 0.59; 95%?CI: 0.38 to 0.88). Stratified by household income, a positive association with EIB was observed only in the group with the highest household income and an inverse association with EBF was found in both low household and high household income groups. CONCLUSIONS:Mothers with a higher education were more likely to initiate early breast feeding when they were also from a high-income household while also being less likely to exclusively breast feed their babies. Routine and successful nursing is crucial for the health of infants and is influenced by maternal education. Future public health interventions to promote breast feeding should consider the issues related to the educational level of mothers.