Dataset Information

Association between serum ?-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

ABSTRACT:

Objective

The purpose of this study was to determine the relationship between serum ?-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.

Design

A cross-sectional study.

Setting

A health check-up centre in Japan.

Participants

912 Japanese men and women aged 24-84?years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV.

Main outcome measures

We measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1?year after the cessation of menses.

Results

In women, log2 GGT was positively associated with baPWV (?=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log2 GGT with baPWV was not significant (?=-0.04, 95% CI -0.10 to 0.03, p=0.28) in multivariable linear regression analyses.

Conclusions

The serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.

SUBMITTER: Fukuda T

PROVIDER: S-EPMC4187458 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Publications

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

Fukuda Takuya T Hamaguchi Masahide M Kojima Takao T Ohshima Yasuhiro Y Ohbora Akihiro A Kato Takahiro T Nakamura Naoto N Fukui Michiaki M

BMJ open 20141003 10

<h4>Objective</h4>The purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.<h4>Design</h4>A cross-sectional study.<h4>Setting</h4>A health check-up centre in Japan.<h4>Participants</h4>912 Japanese men and women aged 24-84 years recruited from people who received a medical health check-up programme with a stan ...[more]

PMID: 25280803

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