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The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.

ABSTRACT: Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance.

SUBMITTER: Boender AJ

PROVIDER: S-EPMC4187548 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.

Boender Arjen J AJ van Gestel Margriet A MA Garner Keith M KM Luijendijk Mieneke C M MC Adan Roger A H RA

Physiological reports 20140730 7

Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our ...[more]

PMID: 25077509

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