The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system.
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ABSTRACT:
SUBMITTER: Kwun MJ
PROVIDER: S-EPMC4187914 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system.
Kwun Min Jung MJ Hong Hee-Jeon HJ
Antimicrobial agents and chemotherapy 20140804 10
Glycopeptide antibiotics containing a hydrophobic substituent display the best activity against vancomycin-resistant enterococci, and they have been assumed to be poor inducers of the resistance system. Using a panel of 26 glycopeptide derivatives and the model resistance system in Streptomyces coelicolor, we confirmed this hypothesis at the level of transcription. Identification of the structural glycopeptide features associated with inducing the expression of resistance genes has important imp ...[more]
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