Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants.

ABSTRACT:

Purpose

To determine genetic variants associated with severe retinopathy of prematurity (ROP) in a candidate gene cohort study of US preterm infants.

Methods

Preterm infants in the discovery cohort were enrolled through the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, and those in the replication cohort were from the University of Iowa. All infants were phenotyped for ROP severity. Because of differences in the durations of enrollment between cohorts, severe ROP was defined as threshold disease in the discovery cohort and as threshold disease or type 1 ROP in the replication cohort. Whole genome amplified DNA from stored blood spot samples from the Neonatal Research Network biorepository was genotyped using an Ill

SUBMITTER: Hartnett ME 

PROVIDER: S-EPMC4188045 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature