Tolerability, effectiveness and predictive parameters for the therapeutic usefulness of exenatide in obese, Korean patients with type 2 diabetes.

ABSTRACT:

Aims/introduction

We assessed the tolerability, effectiveness and predictive parameters for the therapeutic usefulness of exenatide in obese Korean participants with type 2 diabetes. We also evaluated the characteristics of participants who respond adequately to glucagon-like peptide-1 (GLP-1) analog therapy in terms of glycated hemoglobin (HbA1c) level reductions and weight loss.

Materials and methods

This prospective, observational, single-arm (exenatide b.i.d. in combination with both metformin and sulphonylurea), open-label study of GLP-1 analog treatment with close monitoring of metabolic parameters and weight changes was carried out for up to 22 weeks.

Results

Of the 110 enrolled obese participants, 37 participants dropped out during the 22-week treatment period

SUBMITTER: Song SO 

PROVIDER: S-EPMC4188114 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature