Dataset Information

Prediction of acute respiratory disease in current and former smokers with and without COPD.

ABSTRACT:

Background

The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown.

Methods

Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score.

Results

At enrollment, 4,442 subjects did not have COPD, 658 had mild COPD, and 3,146 had moderate or worse COPD. Nine thousand three hundred three acute episodes of respiratory disease and 2,707 hospitalizations were reported in LFU (3,044 acute episodes of respiratory disease and 827 hospitalizations in those without COPD). Major predictors included acute episodes of respiratory disease in year prior to enrollment (HR, 1.20; 95% CI, 1.15-1.24 per exacerbation), airflow obstruction (HR, 0.94; 95% CI, 0.91-0.96 per 10% change in % predicted FEV1), and poor health-related quality of life (HR, 1.07; 95% CI, 1.06-1.08 for each 4-unit increase in St. George's Respiratory Questionnaire score). Risks were similar for those with and without COPD.

Conclusions

Although acute episode of respiratory disease rates are higher in subjects with COPD, risk factors are similar, and at a population level, there are more episodes in smokers without COPD.

SUBMITTER: Bowler RP

PROVIDER: S-EPMC4188150 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Publications

Prediction of acute respiratory disease in current and former smokers with and without COPD.

Bowler Russell P RP Kim Victor V Regan Elizabeth E Williams André A A AAA Santorico Stephanie A SA Make Barry J BJ Lynch David A DA Hokanson John E JE Washko George R GR Bercz Peter P Soler Xavier X Marchetti Nathaniel N Criner Gerard J GJ Ramsdell Joe J Han MeiLan K MK Demeo Dawn D Anzueto Antonio A Comellas Alejandro A Crapo James D JD Dransfield Mark M Wells J Michael JM Hersh Craig P CP MacIntyre Neil N Martinez Fernando F Nath Hrudaya P HP Niewoehner Dennis D Sciurba Frank F Sharafkhaneh Amir A Silverman Edwin K EK van Beek Edwin J R EJR Wilson Carla C Wendt Christine C Wise Robert A RA

Chest 20141001 4

<h4>Background</h4>The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown.<h4>Methods</h4>Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regres ...[more]

PMID: 24945159

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Dataset Information

Prediction of acute respiratory disease in current and former smokers with and without COPD.

Background

Methods

Results

Conclusions

Publications

Prediction of acute respiratory disease in current and former smokers with and without COPD.

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