The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: a systematic review.

ABSTRACT:

Background

A high level of resistance in Neisseria gonorrhoeae has developed against penicillins, sulphonamides, tetracyclines and quinolones, and recent surveillance data have shown a gradual reduction in sensitivity to current first-line agents with an upward drift in the minimum inhibitory concentration of ceftriaxone. Laboratory sensitivity testing suggests that gentamicin, an aminoglycoside, may be an effective treatment option for gonorrhoea infection when used as a single intramuscular dose.

Methods

A search of electronic reference databases and grey literature was used to identify randomised trials and well-conducted prospective studies with concurrent controls evaluating single-dose gentamicin against placebo or a comparator regimen in the treatment of uncomplicated

SUBMITTER: Hathorn E 

PROVIDER: S-EPMC4188483 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature