Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.
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ABSTRACT:
SUBMITTER: Xu JY
PROVIDER: S-EPMC4188900 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.
Xu Jiao-Ya JY Li Zhong-Ping ZP Zhang Li L Ji Guang G
World journal of gastroenterology 20141001 37
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular carcinoma. However, the pathogenesis of NAFLD is complex, and no efficient pharmaceutic treatments have yet been established for NAFLD. Accumulating data have shown that the farnesoid X receptor (FXR) plays important roles not only in bile acid metabo ...[more]
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