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Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients.


ABSTRACT: To determine the frequency of occult hepatitis B infection (OHBI) in a group of human immunodeficiency virus (HIV)-1+/ hepatitis B surface antigen negative (HBsAg)- patients from Mexico.We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus (HBV) DNA was analyzed using nested PCR to amplify the Core (C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's ?(2) and/or Fisher's exact test.We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio (OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIV-antiretroviral treatment with drugs that interfere with HBV replication (lamivudine, tenofovir or emtricitabine) (OR = 0.25; P = 0.05; 95%CI: 0.08-1.05).The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV.

SUBMITTER: Alvarez-Munoz MT 

PROVIDER: S-EPMC4188904 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients.

Alvarez-Muñoz Ma Teresa MT   Maldonado-Rodriguez Angelica A   Rojas-Montes Othon O   Torres-Ibarra Rocio R   Gutierrez-Escolano Fernanda F   Vazquez-Rosales Guillermo G   Gomez Alejandro A   Muñoz Onofre O   Torres Javier J   Lira Rosalia R  

World journal of gastroenterology 20141001 37


<h4>Aim</h4>To determine the frequency of occult hepatitis B infection (OHBI) in a group of human immunodeficiency virus (HIV)-1+/ hepatitis B surface antigen negative (HBsAg)- patients from Mexico.<h4>Methods</h4>We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus (HBV) DNA was analyzed using nested PCR to amplify the Core (C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were inves  ...[more]

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