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Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures.

ABSTRACT: Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.

SUBMITTER: Solanki A

PROVIDER: S-EPMC4189106 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures.

Solanki Aniruddh A Chueng Sy-Tsong Dean ST Yin Perry T PT Kappera Rajesh R Chhowalla Manish M Lee Ki-Bum KB

Advanced materials (Deerfield Beach, Fla.) 20130704 38

Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine. ...[more]

PMID: 23824715

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