Ontology highlight
ABSTRACT:
SUBMITTER: Compton JL
PROVIDER: S-EPMC4189826 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Compton Jonathan L JL Luo Justin C JC Ma Huan H Botvinick Elliot E Venugopalan Vasan V
Nature photonics 20140901
We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics. These μCBs expose adherent cells to a microTsunami, a transient microscale burst of hydrodynamic shear stress, which stimulates cells over areas approaching 1mm<sup>2</sup>. We demonstr ...[more]