Ontology highlight
ABSTRACT:
SUBMITTER: Tabet F
PROVIDER: S-EPMC4189962 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Tabet Fatiha F Vickers Kasey C KC Cuesta Torres Luisa F LF Wiese Carrie B CB Shoucri Bassem M BM Lambert Gilles G Catherinet Claire C Prado-Lourenco Leonel L Levin Michael G MG Thacker Seth S Sethupathy Praveen P Barter Philip J PJ Remaley Alan T AT Rye Kerry-Anne KA
Nature communications 20140228
High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppresses expression of intercellular adhesion molecule 1 (ICAM-1) through the transfer of miR-223 to endothelial cells. After incubation of endothelial cells with HDL, mature miR-223 levels are significantly increased in endothelial cells and decreased o ...[more]