Adult-onset immunodeficiency in Thailand and Taiwan.

ABSTRACT:

Background

Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown.

Methods

We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infection, with or without nontuberculous mycobacterial infection (group 2); 9 patients with disseminated tuberculosis (group 3); 49 patients with pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical histories were recorded, and blood specimens were obtained.

Results

Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to those in patients

SUBMITTER: Browne SK 

PROVIDER: S-EPMC4190026 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature