Ontology highlight
ABSTRACT:
SUBMITTER: Venkatasubramanian R
PROVIDER: S-EPMC4190075 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Venkatasubramanian Raja R Fukuda Tsuyoshi T Niu Jing J Mizuno Tomoyuki T Chidambaran Vidya V Vinks Alexander A AA Sadhasivam Senthilkumar S
Pharmacogenomics 20140701 10
<h4>Aim</h4>Large interindividual variability in morphine pharmacokinetics could contribute to variability in morphine analgesia and adverse events.<h4>Methods</h4>Influence of weight, genetic polymorphisms, race and sex on morphine clearance and metabolite formation from 220 children undergoing outpatient adenotonsillectomy was studied. A nonlinear mixed effects model was developed in NONMEM to describe morphine and morphine glucuronide pharmacokinetics.<h4>Results</h4>Children with ABCC3 -211C ...[more]