Is the comprehension of idiomatic sentences indeed impaired in paranoid Schizophrenia? A window into semantic processing deficits.
Ontology highlight
ABSTRACT:
SUBMITTER: Pesciarelli F
PROVIDER: S-EPMC4190991 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:This event-related potential (ERP) study examines the influence of dialectal competence differences (merged vs. unmerged dialect group) on cross-dialectal comprehension between Southern German dialects. It focuses on the question as to whether certain dialect phonemes (/[Formula: see text]/, /[Formula: see text]/), which are attributed to different lexemes in two dialect areas (Central Bavarian, Bavarian-Alemannic transition zone) evoke increased neural costs during sentence processing. In this context, the phonological and semantic processing of lexemes is compared in three types of potentially problematic communication settings (misunderstanding, incomprehension, allophonic variation = potential comprehension). For this purpose, an oddball design including whole sentences was combined with a semantic rating task. Listeners from the unmerged Central Bavarian dialect area heard sentences including either native or non-native lexemes from the merged neighboring dialect. These had to be evaluated with regard to their context acceptability. The main difference between the lexemes can be attributed to the fact that they have different meanings in the respective dialect areas or are non-existent in the linguistic competence of the Central Bavarians. The results provide evidence for the fact that non-native lexemes containing the /[Formula: see text]/-diphthong lead to enhanced neural costs during sentence processing. The ERP results show a biphasic pattern (N2b/N400, LPC) for non-existent lexemes (incomprehension) as well as for semantically incongruous lexemes (misunderstanding), reflecting an early error detection mechanism and enhanced costs for semantic integration and evaluation. In contrast, allophonic /[Formula: see text]/ deviations show reduced negativities and no LPC, indexing an unproblematic categorization and evaluation process. In the light of these results, an observed change of /[Formula: see text]/ to /[Formula: see text]/ in the Bavarian-Alemannic transition zone can be interpreted as a facilitation strategy of cross-dialectal comprehension to reduce both misunderstandings as well as neural costs in processing, which might be interpreted as the initial trigger for this particular phoneme change.
| S-EPMC4882417 | biostudies-literature
Project description:Several studies indicate the functional importance of the motor cortex for higher cognition, language and semantic processing, and place the neural substrate of these processes in sensorimotor action-perception circuits linking motor, sensory and perisylvian language regions. Interestingly, in individuals with autism spectrum disorder (ASD), semantic processing of action and emotion words seems to be impaired and is associated with hypoactivity of the motor cortex during semantic processing. In this study, the relationship between semantic processing, fine motor skills and clinical symptoms was investigated in 19 individuals with ASD and 22 typically-developing matched controls. Participants completed two semantic decision tasks involving words from different semantic categories, a test of alexithymia (the Toronto Alexithymia Scale), and a test of fine motor skills (the Purdue Pegboard Test). A significant Group × Word Category interaction in accuracy (p < 0.05) demonstrated impaired semantic processing for action words, but not object words in the autistic group. There was no significant group difference when processing abstract emotional words or abstract neutral words. Moreover, our study revealed deficits in fine motor skills as well as evidence for alexithymia in the ASD group, but not in neurotypical controls. However, these motor deficits did not correlate significantly with impairments in action-semantic processing. We interpret the data in terms of an underlying dysfunction of the action-perception system in ASD and its specific impact on semantic language processing.
| S-EPMC6669914 | biostudies-literature
Project description:Despite schizophrenia patients' reports of diminished experience of emotion in interviews and self-report measures, their emotional experience in the presence of emotional stimuli and in daily life ("in the moment") appears largely intact. To examine emotion-cognition interactions, the authors tested the hypothesis that schizophrenia patients have unimpaired in-the-moment emotional reactivity but have a deficit in prefrontal cortical mechanisms needed to maintain and report on experience following exposure to emotional stimuli.Using a slow event-related functional MRI paradigm, the authors examined the brain activity of 23 schizophrenia patients and 24 healthy comparison subjects during trials in which they viewed an affective picture and, after a delay, reported their emotional experience while viewing it.The patients' self-reports of emotional experience differed from those of the healthy subjects when they rated their experience on dimensions inconsistent with the stimulus valence but not when the dimension was consistent with it. In the presence of emotional stimuli, brain activity in the patients was similar to that of the comparison subjects. During the delay, however, patients showed decreased activation in a network of brain structures, including the dorsolateral prefrontal cortex and other prefrontal, limbic, and paralimbic areas. In patients, the delay-related response of the dorsolateral prefrontal cortex to pleasant stimuli correlated negatively with an anhedonia measure.These results suggest that schizophrenia is characterized by a failure of prefrontal circuitry supporting the link between emotion and goal-directed behavior and that the failure of this mechanism may contribute to deficits in processes related to emotion-cognition interaction.
| S-EPMC4019338 | biostudies-literature
Project description:Purpose The goal of this study was to develop and validate a new corpus of sentences without semantic context to facilitate research aimed at isolating the effects of semantic context in speech perception. Method The newly developed corpus contains nonsensical sentences but is matched in vocabulary and syntactic structure to the existing Basic English Lexicon (BEL) corpus. It consists of 20 lists, with each list containing 25 sentences and each sentence having four keywords. Each new list contains the same keywords as the respective list in the original BEL corpus, but the keywords within each list are scrambled across sentences to eliminate semantic context within each sentence, while maintaining the original syntactic structure. All sentences in the original and nonsense BEL corpora were recorded by the same two male and two female talkers. Results Mean intelligibility scores for each list were estimated by calculating the mean proportion of correct keywords achieved by 40 normal-hearing listeners for one male and one female talker. Although small but significant differences were found between some pairs of lists, mean performance for all 20 lists fell within the 95% confidence intervals of the mean. Conclusions Lists in the newly developed nonsense corpus are reasonably well equated for difficulty and can be used interchangeably in a randomized experimental design. Both the original and nonsense BEL sentences, all recorded by the same four talkers, are publicly available. Supplemental Material https://doi.org/10.23641/asha.13022900.
| S-EPMC8582750 | biostudies-literature
Project description:Repeating a word can have both facilitative and inhibitory effects on subsequent processing. The present study investigated these dynamics by examining the facilitative and inhibitory consequences of different kinds of item repetition in two individuals with aphasia and a group of neurologically intact control participants. The two individuals with aphasia were matched on overall aphasia severity, but had deficits at different levels of processing: one with a phonological deficit and spared semantic processing, the other with a semantic deficit and spared phonological processing. Participants completed a spoken word-to-picture matching task in which they had to pick which of four object images matched the spoken word. The trials were grouped into pairs such that exactly two objects from the first trial in a pair were present on screen during the second trial in the pair. When the second trial's target was the same as the first trial's target, compared to control participants, both participants with aphasia exhibited equally larger repetition priming effects. When the second trial's target was one of the new items, the participant with a phonological deficit exhibited a significantly more negative effect (i.e., second trial response slower than first trial response) than the control participants and the participant with a semantic deficit. Simulations of a computational model confirmed that this pattern of results could arise from (1) normal residual activation being functionally more significant when overall lexical processing is slower and (2) residual phonological activation of the previous trial's target having a particularly strong inhibitory effect specifically when phonological processing is impaired because the task was phonologically-driven (the spoken input specified the target). These results provide new insights into perseveration errors and lexical access deficits in aphasia.
| S-EPMC3779605 | biostudies-literature
Project description:Kallmann syndrome (KS) is a genetically heterogeneous and rare disorder characterised by the combination of hypothalamic hypogonadism and anosmia/hyposmia, a variable degree of intellectual disability and several somatic anomalies. In about one-third of the patients, mutations have been identified in at least seven different genes. Virtually no data are available about possible neuropsychiatric symptoms in KS. Here, a young adult male is described with a previous clinical diagnosis of KS and recent paranoid schizophrenia of which positive, but not negative symptoms, fully remitted upon treatment with antipsychotics. Neither genome-wide array analysis nor mutation analyses disclosed imbalances or mutations in any of presently known KS disease genes. This is the first report on a patient with KS and paranoid schizophrenia in whom extensive genetic analyses were performed. It is concluded that further studies are warranted in order to elucidate a possible increased risk for psychiatric symptoms in patients with KS.
| S-EPMC3604460 | biostudies-literature
Project description:The ability to speak coherently, maintaining focus on the topic at hand, is critical for effective communication and is commonly impaired following brain damage. Recent data suggests that executive processes that regulate access to semantic knowledge (i.e., semantic control) are critical for maintaining coherence during speech. To test this hypothesis, we assessed speech coherence in a case-series of stroke patients who exhibited deficits in semantic control. Patients were asked to speak about a series of topics and their responses were analysed using computational linguistic methods to derive measures of their global coherence (the degree to which they spoke about the topic given) and local coherence (the degree to which they maintained a topic from one utterance to the next). Compared with age-matched controls, patients showed severe impairments to global coherence but not to local coherence. Global coherence was strongly correlated with the patients' performance on tests of semantic control, with greater semantic control deficits associated with poorer ability to maintain global coherence. Other aspects of speech production were also impaired but were not significantly correlated with semantic control deficits. These results suggest that semantic control deficits give rise to speech that is poorly regulated at the macrolinguistic "message" level. The preservation of local coherence in the patients suggests that automatic activation of semantic associations is relatively intact, such that each utterance they produce is connected meaningfully to the next. However, in the absence of control processes to constrain semantic activation, the content of their speech becomes increasingly distant from the original topic of discourse. This study is the first to investigate the impact of semantic control impairments on speech production at the discourse level and suggests that patients with these impairments are likely to have difficulties maintaining coherence in conversation.
| S-EPMC7534040 | biostudies-literature
Project description:Catecholamine (CA) function has been widely implicated in cognitive functions that are tied to the prefrontal cortex and striatal areas. The present study investigated the effects of methylphenidate, which is a CA agonist, on the electroencephalogram (EEG) response related to semantic processing using a double-blind, placebo-controlled, randomized, crossover, within-subject design. Forty-eight healthy participants read semantically congruent or incongruent sentences after receiving 20-mg methylphenidate or a placebo while their brain activity was monitored with EEG. To probe whether the catecholaminergic modulation is task-dependent, in one condition participants had to focus on comprehending the sentences, while in the other condition, they only had to attend to the font size of the sentence. The results demonstrate that methylphenidate has a task-dependent effect on semantic processing. Compared to placebo, when semantic processing was task-irrelevant, methylphenidate enhanced the detection of semantic incongruence as indexed by a larger N400 amplitude in the incongruent sentences; when semantic processing was task-relevant, methylphenidate induced a larger N400 amplitude in the semantically congruent condition, which was followed by a larger late positive complex effect. These results suggest that CA-related neurotransmitters influence language processing, possibly through the projections between the prefrontal cortex and the striatum, which contain many CA receptors.
| S-EPMC7609945 | biostudies-literature
Project description:Ophthalmological methods have increasingly raised the interest of neuropsychiatric specialists. While the integrity of the retinal cell functions can be evaluated with the electroretinogram (ERG), optical coherence tomography (OCT) allows a structural investigation of retinal layer thicknesses. Previous studies indicate possible functional and structural retinal alterations in patients with schizophrenia. Twenty-five patients with paranoid schizophrenia and 25 healthy controls (HC) matched for age, sex, and smoking status participated in this study. Both, ERG and OCT were applied to obtain further insights into functional and structural retinal alterations. A significantly reduced a-wave amplitude and thickness of the corresponding para- and perifoveal outer nuclear layer (ONL) was detected in patients with paranoid schizophrenia with a positive correlation between both measurement parameters. Amplitude and peak time of the photopic negative response (PhNR) and thickness of the parafoveal ganglion cell layer (GCL) were decreased in patients with schizophrenia compared to HC. Our results show both structural and functional retinal differences between patients with paranoid schizophrenia and HC. We therefore recommend the comprehensive assessment of the visual system of patients with schizophrenia, especially to further investigate the effect of antipsychotic medication, the duration of illness, or other factors such as inflammatory or neurodegenerative processes. Moreover, longitudinal studies are required to investigate whether the functional alterations precede the structural changes.
| S-EPMC9508100 | biostudies-literature
Project description:Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.
| S-EPMC4722529 | biostudies-literature