Ontology highlight
ABSTRACT:
SUBMITTER: Sachdeva M
PROVIDER: S-EPMC4191039 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Sachdeva Mohit M Mito Jeffrey K JK Lee Chang-Lung CL Zhang Minsi M Li Zhizhong Z Dodd Rebecca D RD Cason David D Luo Lixia L Ma Yan Y Van Mater David D Gladdy Rebecca R Lev Dina C DC Cardona Diana M DM Kirsch David G DG
The Journal of clinical investigation 20140902 10
Metastasis causes most cancer deaths, but is incompletely understood. MicroRNAs can regulate metastasis, but it is not known whether a single miRNA can regulate metastasis in primary cancer models in vivo. We compared the expression of miRNAs in metastatic and nonmetastatic primary mouse sarcomas and found that microRNA-182 (miR-182) was markedly overexpressed in some tumors that metastasized to the lungs. By utilizing genetically engineered mice with either deletion of or overexpression of miR- ...[more]