Ontology highlight
ABSTRACT:
SUBMITTER: Villate O
PROVIDER: S-EPMC4191425 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nucleic acids research 20140923 18
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the 'neuron-specific' Nova1 splicing factor is expressed in pancreatic beta cells. We have presently coupled specific knockdown (KD) of Nova1 with RNA-sequencing to determine all splice variants and downstream pathways regula ...[more]