Mathematical model of renal interstitial fibrosis.
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ABSTRACT:
SUBMITTER: Hao W
PROVIDER: S-EPMC4191765 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Mathematical model of renal interstitial fibrosis.
Hao Wenrui W Rovin Brad H BH Friedman Avner A
Proceedings of the National Academy of Sciences of the United States of America 20140915 39
Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment of the kidney, leading first to interstitial inflammation and subsequently to interstitial fibrosis and atrophy of the renal tubules if not appropriately treated. Presently the only ...[more]
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