Ontology highlight
ABSTRACT:
SUBMITTER: Pierdominici-Sottile G
PROVIDER: S-EPMC4192007 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141009 10
The enzyme UDP-Galactopyranose Mutase (UGM) catalyses the conversion of galactopyranose into galactofuranose. It is known to be critical for the survival and proliferation of several pathogenic agents, both prokaryotic and eukaryotic. Among them is Trypanosoma cruzi, the parasite responsible for Chagas' disease. Since the enzyme is not present in mammals, it appears as a promising target for the design of drugs to treat this illness. A precise knowledge of the mechanism of the catalysed reaction ...[more]