Ontology highlight
ABSTRACT:
SUBMITTER: Herranz D
PROVIDER: S-EPMC4192073 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Herranz Daniel D Ambesi-Impiombato Alberto A Palomero Teresa T Schnell Stephanie A SA Belver Laura L Wendorff Agnieszka A AA Xu Luyao L Castillo-Martin Mireia M Llobet-Navás David D Cordon-Cardo Carlos C Clappier Emmanuelle E Soulier Jean J Ferrando Adolfo A AA
Nature medicine 20140907 10
Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on the analysis of protein-coding genes; however, most genetic abnormalities found in human cancer are located in intergenic regions. Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications in human T cell acute lymphoblastic leukemia (T-ALL). This highly conserved regulatory element, hereby named N-Me for NOTCH MYC enhancer, is loca ...[more]