Ontology highlight
ABSTRACT:
SUBMITTER: Bentley L
PROVIDER: S-EPMC4192286 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Bentley Liz L Esapa Christopher T CT Nesbit M Andrew MA Head Rosie A RA Evans Holly H Lath Darren D Scudamore Cheryl L CL Hough Tertius A TA Podrini Christine C Hannan Fadil M FM Fraser William D WD Croucher Peter I PI Brown Matthew A MA Brown Steve D M SD Cox Roger D RD Thakker Rajesh V RV
Endocrinology 20131203 3
Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, which significantly increased luciferase reporter activity and was thus a gain-of-function m ...[more]