Ontology highlight
ABSTRACT:
SUBMITTER: Trudel S
PROVIDER: S-EPMC4192296 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Trudel Stéphanie S Odolczyk Norbert N Dremaux Julie J Toffin Jérôme J Regnier Aline A Sevestre Henri H Zielenkiewicz Piotr P Arnault Jean-Philippe JP Gubler Brigitte B
BMC cancer 20140929
<h4>Background</h4>Mutations in the activation segment of the v-raf murine sarcoma viral oncogene homolog B (BRAF) gene are present in approximately 50% of melanomas. The selective BRAF inhibitor vemurafenib has demonstrated significant clinical benefits in patients with melanomas harboring the most common mutations (V600E, V600K and V600R). However, the clinical activity of BRAF inhibitors in patients with rare mutations of codon 600 and the surrounding codons has not been documented.<h4>Case p ...[more]